Limburg M, van Royen E A, Hijdra A, Verbeeten B
Department of Neurology, Nuclear Medicine, Academisch Medisch Centrum, Amsterdam, The Netherlands.
J Nucl Med. 1991 Mar;32(3):382-7.
We prospectively studied 26 patients with ischemic stroke within 24 hr, after 2 wk, and after 6 mo with thallium-201-diethyldithiocarbamate single-photon emission computed tomography (SPECT) and neurologic and functional assessments. The admission flow deficits correlated with outcome. The admission and 6-mo scores correlated with clinical conditions at each time. At 2 wk, the flow deficits were smaller and did not correlate with clinical parameters. Nor did the presence or absence of hyperfixation of the radiopharmaceutical. Six months after the infarct, the flow defect had decreased in 9 of 15 patients in whom three serial scans were available, with better clinical improvement than in the remaining six whose flow deficits increased. More patients in the first group had been treated randomly with the calcium-entry blocker flunarizine. SPECT imaging of rCBF within 24 hr after stroke correlates with clinical outcome and condition, whereas rCBF imaging at 2 wk after the stroke shows no clinical correlation.
我们对26例缺血性中风患者进行了前瞻性研究，分别在发病24小时内、2周后和6个月后进行铊-201-二乙基二硫代氨基甲酸盐单光子发射计算机断层扫描（SPECT）以及神经学和功能评估。入院时的血流缺损与预后相关。入院时和6个月时的评分与各时间点的临床状况相关。在2周时，血流缺损较小，且与临床参数无关。放射性药物的高摄取与否也与之无关。在梗死6个月后，15例接受了三次连续扫描的患者中有9例血流缺损有所减少，其临床改善情况优于其余6例血流缺损增加的患者。第一组中更多患者被随机给予钙通道阻滞剂氟桂利嗪治疗。中风后24小时内的rCBF SPECT成像与临床预后和状况相关，而中风后2周的rCBF成像与临床无关。
