Lessey B A, Castelbaum A J, Buck C A, Lei Y, Yowell C W, Sun J
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599-7570.
Fertil Steril. 1994 Sep;62(3):497-506.
To profile the changes in integrin expression in cycling and pregnant endometrium.
Immunohistochemistry was performed on endometrium from proliferative, early, and midsecretory phase and early pregnancy using a blinded panel of monoclonal antibodies directed against integrins. Closer examination of the cycle-dependent integrins was performed in 112 patients throughout the cycle and from the first trimester of pregnancy.
An academic teaching hospital.
Ovulatory women or women undergoing pregnancy termination.
Staining intensity of each antibody in epithelial or stromal cells.
Certain integrins were present constitutively throughout the menstrual cycle whereas others were expressed only during the luteal phase. Four integrins increased in the decidua of pregnancy. The timing of expression of the two cycle-dependent integrins (alpha 4 beta 1 and alpha v beta 3) framed the putative window of implantation and suggests a role in establishment of uterine receptivity.
Our findings confirm the patterns of endometrial integrins and suggest important roles for integrins in the process of implantation and decidualization.
剖析周期性及妊娠子宫内膜中整合素表达的变化。
运用一组针对整合素的单克隆抗体，对增殖期、分泌期早期、分泌期中段及妊娠早期的子宫内膜进行免疫组织化学检测，检测过程采用盲法。对112例患者整个月经周期及妊娠早期的周期性整合素进行了更深入的研究。
一家学术教学医院。
有排卵的女性或接受妊娠终止的女性。
每种抗体在上皮细胞或基质细胞中的染色强度。
某些整合素在整个月经周期中持续存在，而其他整合素仅在黄体期表达。四种整合素在妊娠蜕膜中增加。两种周期性整合素（α4β1和αvβ3）的表达时间确定了假定的着床窗，并提示其在子宫容受性建立中的作用。
我们的研究结果证实了子宫内膜整合素的模式，并提示整合素在着床和蜕膜化过程中发挥重要作用。
