Sequence of the penicillin-binding protein 2-encoding gene (penA) of Neisseria perflava/sicca.

The nucleotide sequence of the transpeptidase domain (Tp) of the penicillin (Pn)-binding protein 2-encoding gene (penA) from two Pn-sensitive (PnS) and two Pn-resistant (PnR) strains of Neisseria perflava/sicca, has been determined. The sequences from PnS strains, although displaying high homology with those PnS strains from other Neisseria species, also showed several interesting modifications suggesting that these isolates might represent intermediates in the mutational development of PnR in N. perflava/sicca.