生长抑素：促甲状腺激素释放激素作用后对促甲状腺激素和催乳素分泌的影响
Growth hormone release inhibiting hormone: actions on thyrotrophin and prolactin secretion after thyrotrophinreleasing hormone.
作者信息
Carr D, Gomez-Pan A, Weightman D R, Roy V C, Hall R, Besser G M, Thorner M O, McNeilly A S, Schally A V, Kastin A J, Coy D H
出版信息
Br Med J. 1975 Jul 12;3(5975):67-9. doi: 10.1136/bmj.3.5975.67.
Abstract
The hypothalamic tetradecapeptide growth hormone release inhibiting hormone (GH-RIH) blocked the thyrotrophin response to thyrotrophin-releasing hormone (TRH) in normal people and in patients with primary hypothyroidism. This inhibition was dose related. The TRH-induced prolactin release was not affected by GH-RIH. This dissociation of the thyrotrophin and prolactin responses to TRH by GH-RIH suggests that there are different mechanisms for release of thyrotrophin and prolactin and that only the former is affected by GH-RIH.
摘要
下丘脑十四肽生长激素释放抑制激素（GH-RIH）可阻断正常人及原发性甲状腺功能减退患者促甲状腺激素对促甲状腺激素释放激素（TRH）的反应。这种抑制作用与剂量相关。TRH诱导的催乳素释放不受GH-RIH影响。GH-RIH使促甲状腺激素和催乳素对TRH的反应出现这种分离，提示促甲状腺激素和催乳素的释放机制不同，且只有前者受GH-RIH影响。
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