溴隐亭对正常男性促甲状腺激素释放激素（TRH）刺激的催乳素和促甲状腺素释放的抑制作用以及TRH对溴隐亭诱导的生长激素释放的伴随抑制作用。

Bromocriptine suppression of TRH-stimulated prolactin and thyrotrophin release and accompanying inhibition of bromocriptine induced growth hormone release by TRH in normal man.

作者信息

Brown P M, Bacchus R, Sachs L, Sönksen P H, Wheeler M

出版信息

Clin Endocrinol (Oxf). 1979 May;10(5):481-8. doi: 10.1111/j.1365-2265.1979.tb02104.x.

DOI:10.1111/j.1365-2265.1979.tb02104.x

Abstract

Six normal fasting males received on four separate occasions in random order (1) a placebo tablet followed 60 min later by 200 microgram of TRH intravenously (2) bromocriptine 2.5 mg orally followed by TRH intravenously (3) bromocriptine 2.5 mg orally followed by a placebo injection and (4) placebo tablet followed by placebo injection. Plasma prolactin and TSH responses to TRH were decreased following bromocriptine pretreatment. The rise of plasma growth hormone after bromocriptine was inhibited by TRH. The rise in plasma FSH seen after TRH injection was not influenced by bromocriptine pretreatment. Circulating LH and insulin concentrations were unaffected by any drug administration. These results suggest a dopaminergic influence on prolactin and TSH release in normal men, an inhibitory effect of TRH on bromocriptine stimulated growth hormone secretion, and no dopaminergic modulation of basal insulin secretion.

摘要

六名正常空腹男性在四个不同场合按随机顺序接受了以下处理

（1）服用一片安慰剂，60分钟后静脉注射200微克促甲状腺激素释放激素（TRH）；（2）口服2.5毫克溴隐亭，随后静脉注射TRH；（3）口服2.5毫克溴隐亭，随后注射安慰剂；（4）服用安慰剂片，随后注射安慰剂。溴隐亭预处理后，血浆催乳素和对TRH的促甲状腺激素反应降低。TRH抑制了溴隐亭后血浆生长激素的升高。TRH注射后血浆促卵泡激素（FSH）的升高不受溴隐亭预处理的影响。循环中的促黄体生成素（LH）和胰岛素浓度不受任何药物给药的影响。这些结果表明多巴胺能对正常男性催乳素和促甲状腺激素释放有影响，TRH对溴隐亭刺激的生长激素分泌有抑制作用，且多巴胺能对基础胰岛素分泌无调节作用。