Bellazzi R, Siviero C, Bellazzi R
Dipartimento di Informatica e Sistemistica, Università di Pavia, Italy.
Haematologica. 1994 Mar-Apr;79(2):154-64.
This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.
本文描述了通过使用患者反应的数学模型以及源自工业控制理论的给药控制策略，在尿毒症患者的重组人促红细胞生成素（r-HuEPO）治疗中可能实现的改进。文中给出了r-HuEPO作用的数学模型，并展示了其在透析患者中的适用性。此外，总结了一种用于通过分析患者群体来识别数学模型参数的新统计技术，并介绍了基于模糊集控制器的尿毒症患者r-HuEPO给药控制策略。还展示了从模拟中获得的一些结果。
