Namura S, Nishijima S, Mitsuya K, Asada Y
Department of Dermatology, Kansai Medical University, Osaka, Japan.
J Dermatol. 1994 Jun;21(6):405-10. doi: 10.1111/j.1346-8138.1994.tb01763.x.
The effectiveness of quick handwashing in regards to four alcohol-based handrub lotions, including two products already on the market and our original lotions 1, 2, with two different kinds of hand washing machines was studied in vivo. We also tried to evaluate the efficacy of the four lotions in vitro. The in vivo testing of each lotion, including ethanol, was evaluated using two hand washing methods, first with and then without a previous soap wash. Computerized image analysis was used to calculate the bacterial count on the hand surface. The results showed that a 3 second application of the original lotion 2 (0.5% chlorhexidine in a 77% ethyl alcohol solution) preceded by a soap wash eradicated 89.3% of the bacteria on the hands; this was the highest reduction rate of all four detergents. AROKULIN-E (67.9% ethyl alcohol solution) without a prior handwashing produced the lowest reduction, 49.1% against hand surface bacteria. These results were compatible with those in vitro. It seems that an alcohol-based solution containing an effective antimicrobial detergent preceded by a soap wash is necessary to acceptably reduce hand surface bacteria.
我们在体内研究了快速洗手对于四种酒精基洗手液的效果，其中包括两种已上市产品以及我们最初的1号和2号洗手液，并使用了两种不同的洗手设备。我们还尝试在体外评估这四种洗手液的功效。每种洗手液（包括乙醇）的体内测试均使用两种洗手方法进行评估，首先是在之前使用肥皂洗手的情况下，然后是在没有之前使用肥皂洗手的情况下。使用计算机图像分析来计算手部表面的细菌数量。结果显示，在使用肥皂洗手之后，涂抹3秒钟最初的2号洗手液（77%乙醇溶液中含0.5%洗必泰）可清除手上89.3%的细菌；这是所有四种洗涤剂中最高的减少率。未事先洗手的AROKULIN-E（67.9%乙醇溶液）产生的减少率最低，对手部表面细菌的减少率为49.1%。这些结果与体外结果相符。似乎要想令人满意地减少手部表面细菌，有必要先使用肥皂洗手，然后使用含有有效抗菌洗涤剂的酒精基溶液。
