Tsutsui K, Hirone T, Kubo K, Matsui Y
Department of Dermatology, Kanazawa University School of Medicine, Japan.
J Dermatol. 1994 Jun;21(6):426-9. doi: 10.1111/j.1346-8138.1994.tb01767.x.
A case of annular elastolytic giant cell granuloma with a good response to cyclosporin A is reported. A 62-year-old man developed multiple annular patches on the trunk with elevated and indurated borders. Biopsy specimens from the border showed granulomatous inflammation in the mid dermis with phagocytosis of elastic fibers by giant cells. Biopsy specimens from the center showed dense collagen formation without inflammation. Immunological investigation of perivascular infiltrating cells in the lesions revealed a predominance of CD4+ cells over CD8+ cells. Our case showed a good response to cyclosporin A (5 mg/kg/day) for eight weeks. There were no adverse effects and no recurrences for one month after discontinuation of cyclosporin A.
报告了一例对环孢素A反应良好的环状弹性组织溶解性巨细胞肉芽肿病例。一名62岁男性躯干出现多个环状斑块，边界隆起且硬结。取自边界的活检标本显示真皮中部有肉芽肿性炎症，巨细胞吞噬弹性纤维。取自中央的活检标本显示有致密的胶原形成但无炎症。对病变处血管周围浸润细胞的免疫学研究显示CD4 +细胞多于CD8 +细胞。我们的病例对环孢素A（5毫克/千克/天）治疗8周反应良好。停用环孢素A后一个月无不良反应且无复发。
