Mandel I D
Columbia University School of Dental and Oral Surgery.
J Am Dent Assoc. 1994 Aug;125 Suppl 2:2S-10S. doi: 10.1016/s0002-8177(94)14001-x.
The Seal of Acceptance of the American Dental Association's Council on Dental Therapeutics has been awarded to Listerine and chlorhexidine gluconate (Peridex). The mechanism of action of Listerine involves bacterial cell wall destruction, bacterial enzymatic inhibition, and extraction of bacterial lipopolysaccharides. Chlorhexidine has the property of substantivity, i.e. the ability to bind to hard and soft tissue with slow release. Antibacterial mouthrinses/dentifrices containing triclosan hold promise for the reduction of plaque and gingivitis but are not yet available in the United States. The quaternary ammonium compounds and sanguinarine compounds (Viadent) have some merit, but studies of their efficacy in plaque and gingivitis reduction are mixed. New products containing various fluorides and oxygenating agents may have potential for the future as antiplaque and antigingivitis agents.
美国牙科治疗理事会的认可印章已授予李施德林和葡萄糖酸氯己定（派丽奥）。李施德林的作用机制包括破坏细菌细胞壁、抑制细菌酶以及提取细菌脂多糖。氯己定具有持续性，即能够与软硬组织结合并缓慢释放。含三氯生的抗菌漱口水/牙膏有望减少牙菌斑和牙龈炎，但在美国尚未上市。季铵化合物和血根碱化合物（卫得）有一定优点，但关于它们减少牙菌斑和牙龈炎功效的研究结果不一。含各种氟化物和氧化剂的新产品未来可能有作为抗牙菌斑和抗牙龈炎药物的潜力。
