Cheung B M, Brown M J
Department of Medicine, University of Cambridge, UK.
J Hypertens. 1994 Apr;12(4):449-54.
To study the relationship between hypertension and the plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to determine whether the plasma levels of BNP and CNP are correlated.
A cross-sectional study of the plasma levels of BNP and CNP in hypertensive patients and normotensive controls matched for age and sex was performed.
The hypertension research clinic in a teaching hospital and well-person risk factor screening clinics in general practice health centres.
Fifty-four subjects (29 hypertensive, 25 normotensive controls) took part in the study after giving their informed consent. Hypertensive patients (n = 19) were paired with normotensive controls (n = 19) matched for age and sex to form a subgroup before analysis of the plasma.
The plasma levels of BNP and CNP were determined by specific radioimmunoassays.
The mean plasma concentration of BNP was significantly higher in the hypertensive group than in the paired controls. In contrast, the mean plasma concentration of CNP was not significantly different in the hypertensive group than in the paired controls. Multiple regression analysis of all 54 subjects showed that the plasma level of BNP correlated significantly with age and systolic blood pressure, whereas the plasma level of CNP correlated significantly with sex, heart rate and alcohol intake. The CNP levels did not correlate significantly with either systolic or diastolic blood pressure, or with plasma brain natriuretic levels.
Hypertension is associated with raised BNP but not CNP plasma levels.
研究高血压与血浆脑钠肽（BNP）和C型钠尿肽（CNP）水平之间的关系，并确定BNP和CNP的血浆水平是否相关。
对年龄和性别匹配的高血压患者及血压正常对照者的BNP和CNP血浆水平进行横断面研究。
一家教学医院的高血压研究门诊及全科医疗中心的健康危险因素筛查门诊。
54名受试者（29名高血压患者，25名血压正常对照者）在签署知情同意书后参与研究。在分析血浆之前，将高血压患者（n = 19）与年龄和性别匹配的血压正常对照者（n = 19）配对，形成一个亚组。
采用特异性放射免疫分析法测定BNP和CNP的血浆水平。
高血压组的BNP平均血浆浓度显著高于配对对照组。相比之下，高血压组的CNP平均血浆浓度与配对对照组无显著差异。对所有54名受试者进行多元回归分析显示，BNP的血浆水平与年龄和收缩压显著相关，而CNP的血浆水平与性别、心率和酒精摄入量显著相关。CNP水平与收缩压或舒张压以及血浆脑钠肽水平均无显著相关性。
高血压与BNP血浆水平升高有关，但与CNP血浆水平无关。
