Jennings M B
New York College of Podiatric Medicine, New York.
J Am Podiatr Med Assoc. 1994 Jul;84(7):348-54. doi: 10.7547/87507315-84-7-348.
Osteoarthritis is the most common joint disease and the second highest ranking cause of disability in the US. Osteoarthritis commonly affects the hands, wrists, spine, knees, and feet. One of the mainstays of treatment for osteoarthritis is the use of nonsteroidal anti-inflammatory drugs. While there have been controlled comparison studies of the various nonsteroidal anti-inflammatory drugs, these have been limited to osteoarthritis of the hands, spine, and hip. This study was a randomized, double-blind, parallel study of 8 weeks' duration comparing piroxicam (Feldene, 20 mg daily) to naproxen (Naprosyn, 1,000 mg daily) in the treatment of osteoarthritis of the foot in 45 patients. Both groups experienced significant pain relief and improvement of mobility.
骨关节炎是最常见的关节疾病，在美国是导致残疾的第二大原因。骨关节炎通常影响手、手腕、脊柱、膝盖和足部。治疗骨关节炎的主要方法之一是使用非甾体抗炎药。虽然已经对各种非甾体抗炎药进行了对照比较研究，但这些研究仅限于手部、脊柱和髋部的骨关节炎。本研究是一项为期8周的随机、双盲、平行研究，比较了吡罗昔康（ Feldene，每日20毫克）和萘普生（Naprosyn，每日1000毫克）对45例足部骨关节炎的治疗效果。两组患者的疼痛均得到显著缓解，活动能力也有所改善。
