Sautter F J, McDermott B E
Tulane University School of Medicine, Department of Psychiatry and Neurology, New Orleans, LA 70112.
J Psychiatr Res. 1994 Jan-Feb;28(1):97-106. doi: 10.1016/0022-3956(94)90038-8.
This study was designed to determine if familial and nonfamilial forms of schizophrenia show a different short-term illness course. Sixteen familial and 22 nonfamilial schizophrenics were evaluated on three occasions at regular 6-month intervals over an 18-month period. The familial and nonfamilial groups were compared for differences in positive and negative symptoms of psychosis and interpersonal and occupational role functioning. The data show that familial schizophrenics experience significantly higher levels of positive symptoms of psychosis and significantly worse occupational role functioning. Significant time by family history interactions indicates that the negative symptoms and interpersonal role functioning of the familial schizophrenics changed over the course of follow-up while remaining stable over time in the nonfamilial group. These data provide preliminary support for the hypothesis that familial schizophrenics show a higher degree of impairment during follow-up than nonfamilial schizophrenics.
本研究旨在确定家族性和非家族性精神分裂症的短期病程是否存在差异。在18个月的时间里，每隔6个月对16名家族性精神分裂症患者和22名非家族性精神分裂症患者进行三次评估。比较家族性和非家族性两组患者在精神病性阳性和阴性症状以及人际和职业角色功能方面的差异。数据显示，家族性精神分裂症患者经历的精神病性阳性症状水平显著更高，职业角色功能显著更差。家族史与时间的显著交互作用表明，家族性精神分裂症患者的阴性症状和人际角色功能在随访过程中发生了变化，而非家族性组则随时间保持稳定。这些数据为家族性精神分裂症患者在随访期间比非家族性精神分裂症患者表现出更高程度的损害这一假设提供了初步支持。
