Davison J M, Marty J J
Department of Obstetrics and Gynecology, Truman Medical Center, School of Medicine, University of Missouri-Kansas City 64108.
J Reprod Med. 1994 May;39(5):388-92.
The combination of parallel cytology and screening colposcopy was found to increase the detection of premalignant cervical lesions from 8.2% in a group of patients (based on cytology alone) to 15.3% in that group (based on the combination). The combination of the two methods used in parallel increased the sensitivity, negative predictive value and efficiency of cervical cancer screening over cytology alone while having only a small negative impact on the positive predictive value of a positive test. The addition of screening colposcopy to cytology produces a significant improvement over current uniphasic screening protocols.
研究发现，并行细胞学检查与筛查性阴道镜检查相结合，可将一组患者中癌前宫颈病变的检出率从（仅基于细胞学检查时的）8.2%提高至该组（基于联合检查时的）15.3%。并行使用这两种方法，相较于单独使用细胞学检查，提高了宫颈癌筛查的敏感性、阴性预测值和效率，同时对阳性检查结果的阳性预测值仅有较小的负面影响。在细胞学检查基础上增加筛查性阴道镜检查，相较于目前的单相筛查方案有显著改善。
