Lettgen B, Wagner S, Hänze J, Lang R E, Rascher W
Universitätsklinik für Kinder- und Jugendmedizin, Essen, Germany.
J Hum Hypertens. 1994 May;8(5):345-9.
Neuropeptide Y (NPY) has been recently characterised as a circulating vasoconstrictor peptide which is co-stored with noradrenaline (NA) in sympathetic neurons. We measured NPY by radioimmunoassay and NA by HPLC in plasma of ten healthy volunteers (23-27 years of age) during bicycle ergometry and found a rapid increase of both NPY and NA during exercise. NPY rose from 1.3 +/- 0.5 to 9.6 +/- 7.8 pmol/l and NA from 1.3 +/- 0.3 to 10.8 +/- 5.6 mnol/l (mean +/- SD). Following maximal exercise NA disappeared more rapidly from plasma than NPY. Compared with these healthy volunteers, plasma NPY was found to be elevated in 23 children and adolescents aged 9-18 years with borderline primary hypertension (NPY 3.1 +/- 1.7 pmol/l, P < 0.01). Basal NPY was also elevated when compared with 21 age-matched pediatric controls (P < 0.05). The bicycle ergometry protocol performed in 23 patients separated ten adolescents with normal basal and exercise blood pressure from 13 with high BP also during ergometry. In the latter group, NPY rose to 11.9 +/- 7.3 pmol/l and NA to 12.3 +/- 8.6 nmol/l during exercise. Treatment of the hypertensive patients with the beta-adrenergic blocker atenolol (50 mg per day) lowered basal and exercise BP. Heart rate fell during atenolol treatment from 92 +/- 19 to 72 +/- 15 beats/min. Treatment did not alter plasma concentrations under basal conditions and during exercise (NPY from 2.8 +/- 2.1 to 11.7 +/- 5.3 pmol/l and NA from 2.0 +/- 0.8 to 15.6 +/- 14.1 nmol/l).(ABSTRACT TRUNCATED AT 250 WORDS)
神经肽Y（NPY）最近被鉴定为一种循环血管收缩肽，它与去甲肾上腺素（NA）共同储存于交感神经元中。我们通过放射免疫分析法测定了10名健康志愿者（年龄23 - 27岁）在自行车测力计运动期间血浆中的NPY，并通过高效液相色谱法测定了NA，发现运动期间NPY和NA均迅速增加。NPY从1.3±0.5升至9.6±7.8 pmol / l，NA从1.3±0.3升至10.8±5.6 mnol / l（平均值±标准差）。最大运动后，NA从血浆中消失的速度比NPY更快。与这些健康志愿者相比，发现23名9 - 18岁边缘性原发性高血压儿童和青少年的血浆NPY升高（NPY 3.1±1.7 pmol / l，P < 0.01）。与21名年龄匹配的儿科对照相比，基础NPY也升高（P < 0.05）。在23名患者中进行的自行车测力计运动方案也将10名基础和运动血压正常的青少年与13名运动期间血压高的青少年区分开来。在后一组中，运动期间NPY升至11.9±7.3 pmol / l，NA升至12.3±8.6 nmol / l。用β - 肾上腺素能阻滞剂阿替洛尔（每天50 mg）治疗高血压患者可降低基础血压和运动血压。阿替洛尔治疗期间心率从92±19降至72±15次/分钟。治疗未改变基础条件下和运动期间的血浆浓度（NPY从2.8±2.1至11.7±5.3 pmol / l，NA从2.0±0.8至15.6±14.1 nmol / l）。（摘要截断于250字）
