Pruszczyk P, Chlebus M
Department of Hypertension and Angiology, Warsaw Medical Academy, Poland.
Clin Exp Hypertens. 1995 Jul;17(5):769-85. doi: 10.3109/10641969509033634.
The aim or the study was to assess plasma neuropeptide Y immunoreactivity concentration (NPY-ir) during dynamic exercise in pts with different stages of essential hypertension (ESH). We studied 25 males aged 29.4 +/- 6.3 yrs with established ESH (ESH) and 12 healthy males aged 27.3 +/- 5.1 yrs (C). Plasma concentrations of NPY-ir, NA, A, BP were measured before treadmill test, in the last minute of two six-min. work loads corresponding to 60% and 80% of maximal individual load and 30 min. after cessation of exercise. Plasma NPY-ir was evaluated with RIA, NA and A with REA. Gradual exercise resulted in an increase of NPY-ir in ESH (from 14.4 +/- 5.8 to 18.1 +/- 6.4 and 20.7 +/- 8.1 fmol/ml p = 0.036, p = 0.02) and in C (from 11.7 +/- 4.6 to 13.4 +/- 5.0 and 15.2 +/- 5.9 fmol/ml, p < 0.01). Likewise plasma NA and A increased in both groups. Plasma NPY-ir during exercise was significantly higher in ESH than in C (p = 0.041 and p = 0.047) while no such differences were observed in plasma NA and A. According to the left ventricle mass index (LVMI) ESH was divided into two subgroups: with left ventricular hypertrophy (LVH+) n = 10, LVMI = 159.7 +/- 7.7 g/m2 and without the hypertrophy (LVH-) n = 15 LVMI = 112.3 +/- 19.2g/m2. LVH- presented significant increase in plasma NPY-ir during exercise (from 14.7 +/- 5.7 to 18.2 +/- 6.5, 22.8 +/- 8.3 fmol/ml p < 0.01), while no changes in LVH+ were observed (from 14.1 +/- 5.8 to 17.8 +/- 6.0 and 17.8 +/- 6.7 fmol/ml, ns). LVH+ were older than LVH- (33.4 +/- 7.1 yrs vs 26.7 +/- 4.2 p = 0.04), but no correlation between age and plasma NPY-ir was noticed. No differences in plasma NA and A were present between these subgroups.
Patients at different stages of essential hypertension display various patterns of sympatho-adrenal activation during dynamic exercise.
本研究的目的是评估不同阶段原发性高血压（ESH）患者动态运动期间血浆神经肽Y免疫反应性浓度（NPY-ir）。我们研究了25名年龄在29.4±6.3岁的确诊ESH男性患者（ESH组）和12名年龄在27.3±5.1岁的健康男性（C组）。在跑步机测试前、对应于个体最大负荷60%和80%的两个6分钟工作负荷的最后一分钟以及运动停止后30分钟测量血浆NPY-ir、去甲肾上腺素（NA）、肾上腺素（A）和血压（BP）。血浆NPY-ir用放射免疫分析法（RIA）评估，NA和A用放射酶分析法（REA）评估。逐渐增加运动强度导致ESH组NPY-ir升高（从14.4±5.8升至18.1±6.4和20.7±8.1 fmol/ml，p = 0.036，p = 0.02），C组也升高（从11.7±4.6升至13.4±5.0和15.2±5.9 fmol/ml，p < 0.01）。同样，两组血浆NA和A均升高。运动期间ESH组血浆NPY-ir显著高于C组（p = 0.041和p = 0.047），而血浆NA和A未观察到此类差异。根据左心室质量指数（LVMI），ESH患者分为两个亚组：有左心室肥厚（LVH+）n = 10，LVMI = 159.7±7.7 g/m²；无肥厚（LVH-）n = 15，LVMI = 112.3±19.2 g/m²。LVH-亚组运动期间血浆NPY-ir显著升高（从14.7±5.7升至18.2±6.5、22.8±8.3 fmol/ml，p < 0.01），而LVH+亚组未观察到变化（从14.1±5.8升至17.8±6.0和17.8±6.7 fmol/ml，无显著性差异）。LVH+亚组患者年龄大于LVH-亚组（33.4±7.1岁对26.7±4.2岁，p = 0.04），但未发现年龄与血浆NPY-ir之间存在相关性。这些亚组之间血浆NA和A无差异。
原发性高血压不同阶段的患者在动态运动期间表现出不同模式的交感-肾上腺激活。
