Gruskin A B, Dabbagh S, Fleishmann L E, Atiyeh B A
Wayne State University School of Medicine, Department of Pediatrics, Detroit, MI 48201.
J Hum Hypertens. 1994 May;8(5):381-8.
Strategies for using antihypertensive agents have changed significantly since 1980. This paper reviews clinical studies devoted to the use of antihypertensive agents in children beyond the newborn period. The availability of converting enzyme inhibitors and calcium channel blockers has significantly improved BP control in children with secondary forms of hypertension. The role of antihypertensive agents to chronically treat primary hypertension in children remains unclear. Additionally, some treatment protocols used in adults that apply to the treatment of hypertensive children and that have been used in the treatment of nonhypertensive disease are discussed. Preliminary studies suggest that the rate of decline of renal function in some forms of progressive renal disease may be retarded by the use of converting enzyme inhibitors.
自1980年以来，使用抗高血压药物的策略发生了显著变化。本文回顾了针对新生儿期以后儿童使用抗高血压药物的临床研究。转换酶抑制剂和钙通道阻滞剂的出现显著改善了继发性高血压患儿的血压控制。抗高血压药物在长期治疗儿童原发性高血压中的作用仍不明确。此外，还讨论了一些适用于高血压儿童治疗且已用于非高血压疾病治疗的成人治疗方案。初步研究表明，使用转换酶抑制剂可能会延缓某些形式的进行性肾病的肾功能下降速度。
