Kuwano H, Watanabe M, Sadanaga N, Kamakura T, Nozoe T, Yasuda M, Mimori K, Mori M, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Surg Oncol. 1994 Sep;57(1):17-21. doi: 10.1002/jso.2930570106.
A review of 167 cases of esophageal carcinoma without preoperative treatment revealed 24 (14.4%) to have intramural metastasis (IM) within the esophagus. Among the clinicopathologic factors, the length of the lesions (P < 0.01), lymph node metastasis (P < 0.001), and the depth of the invasion of the tumor (P < 0.0001) were found to be statistically significant different factors between the two groups of patients both with and without intramural metastasis. The survival curve for patients with IM was significantly lower than that for patients without IM (P < 0.0001). A univariate analysis revealed that the depth of invasion, lymph node metastasis, IM (P < 0.0001), and the length of the lesion (P < 0.001) all had a significant correlation with the prognosis. Moreover, in a multivariate analysis, the depth of the invasion (< 0.001), length of the lesion (0.001), and IM (0.049) were all determined to be significant prognostic factors. Therefore, IM is considered to be one of the independent significant prognostic factors for predicting a poor prognosis in esophageal cancer.
对167例未经术前治疗的食管癌病例进行回顾发现，24例（14.4%）在食管内存在壁内转移（IM）。在临床病理因素中，发现病变长度（P<0.01）、淋巴结转移（P<0.001）以及肿瘤浸润深度（P<0.0001）在有和无壁内转移的两组患者之间存在统计学显著差异。有壁内转移患者的生存曲线显著低于无壁内转移患者（P<0.0001）。单因素分析显示，浸润深度、淋巴结转移、壁内转移（P<0.0001）以及病变长度（P<0.001）均与预后有显著相关性。此外，在多因素分析中，浸润深度（<0.001）、病变长度（0.001）和壁内转移（0.049）均被确定为显著的预后因素。因此，壁内转移被认为是预测食管癌预后不良的独立显著预后因素之一。
