Jayaram G, Lamba S, Kakar A
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Malays J Pathol. 1993 Dec;15(2):131-6.
Seventy-eight symptomatic females without palpable breast lumps were subjected to bilateral four quadrant fine needle aspiration cytology. Cytological evidence of an epithelial proliferative lesion was seen in 44 of these cases. Based on the cytological evidence of proliferation, the site for open biopsy was determined. Histopathological study of the breast biopsies in these patients showed proliferative disease without atypia (PDWA) in 40 cases, atypical ductal hyperplasia (ADH) in two, atypical lobular hyperplasia (ALH) in one and ADH with ALH in one case. Cytology was thus useful in establishing the presence of proliferative activity, commenting on the extent of proliferation, and thereby roughly mapping out the area of the breast most suitable for biopsy. On cytological grounds, it was not possible to distinguish the atypical hyperplastic lesions from the proliferative diseases without atypia.
78名无明显乳房肿块的有症状女性接受了双侧四象限细针穿刺细胞学检查。其中44例出现上皮增生性病变的细胞学证据。根据增生的细胞学证据确定开放活检部位。对这些患者乳房活检的组织病理学研究显示，40例为无非典型增生性疾病（PDWA），2例为非典型导管增生（ADH），1例为非典型小叶增生（ALH），1例为ADH合并ALH。因此，细胞学有助于确定增生活性的存在，评估增生程度，从而大致确定乳房最适合活检的区域。基于细胞学依据，无法将非典型增生性病变与无非典型增生的增生性疾病区分开来。
