Jayaram G, Gupta M, Lamba S
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Malays J Pathol. 1993 Dec;15(2):137-42.
Forty-eight patients with breast carcinoma were subjected to four quadrant fine needle aspiration (FNA) cytology examination of the ipsilateral and contralateral breast in an attempt to detect any accompanying benign proliferative lesion. Mastectomy of ipsilateral and open biopsy of contralateral breast provided material for histopathological study. Cytological evidence of epithelial proliferation was found in 8 (16.6%) cases which included atypical lobular hyperplasia (ALH), lobular neoplasia in-situ (LNIS), atypical ductal hyperplasia (ADH), and proliferative disease without atypia (PDWA). In lobular proliferative lesions, cytological smears showed configurations of cells that resembled filled up or expanded lobular units. The cytology was not distinctive enough to distinguish the sub-types of lobular proliferations. Likewise, the presence of ductal alterations could be suggested by cytological study but the distinction of proliferative disease without atypia (PDWA) from atypical ductal hyperplasia (ADH) was not possible on a cytological basis.
48例乳腺癌患者接受了患侧和对侧乳房的四象限细针穿刺（FNA）细胞学检查，以试图检测任何伴随的良性增殖性病变。患侧乳房切除术和对侧乳房开放活检为组织病理学研究提供了材料。在8例（16.6%）病例中发现了上皮增殖的细胞学证据，其中包括非典型小叶增生（ALH）、小叶原位瘤（LNIS）、非典型导管增生（ADH）和无异型性的增殖性疾病（PDWA）。在小叶增殖性病变中，细胞学涂片显示细胞形态类似于充满或扩张的小叶单位。细胞学检查不足以区分小叶增殖的亚型。同样，细胞学研究可以提示导管改变的存在，但在细胞学基础上无法区分无异型性的增殖性疾病（PDWA）和非典型导管增生（ADH）。
