Haidar N E, Andriamampandry C, Carrara M, Kanfer J N, Freysz L, Dreyfus H, Massarelli R
Centre de Neurochimie du CNRS, Strasbourg, France.
Neurochem Res. 1994 Apr;19(4):457-62. doi: 10.1007/BF00967324.
The sequential methylation of ethanolamine (Etn) or phosphorylethanolamine to the corresponding choline (Cho) derivatives was studied in both undifferentiated and retinoic acid (RA) differentiated human neuroblastoma clones LA-N-1 and LA-N-2. Conversion of Etn derivatives to the respective Cho metabolites was low in both cell types. However, after treatment of the cultures with ethanol or RA, the methylation of phosphoryl-Etn was stimulated while that of phosphatidyl-Etn was severely reduced in both cholinergic LA-N-2 and catecholaminergic LA-N-1 cells.
在未分化的以及经视黄酸（RA）分化的人神经母细胞瘤克隆LA-N-1和LA-N-2中，研究了乙醇胺（Etn）或磷酸乙醇胺依次甲基化生成相应胆碱（Cho）衍生物的过程。在这两种细胞类型中，Etn衍生物向各自Cho代谢物的转化都很低。然而，在用乙醇或RA处理培养物后，在胆碱能的LA-N-2细胞和儿茶酚胺能的LA-N-1细胞中，磷酸化-Etn的甲基化受到刺激，而磷脂酰-Etn的甲基化则严重减少。
