Malone J P, Snyderman C H
University of Pittsburgh School of Medicine, PA.
Oral Surg Oral Med Oral Pathol. 1994 Jun;77(6):636-40. doi: 10.1016/0030-4220(94)90326-3.
Alterations in the production of arachidonic acid metabolites by squamous epithelium of the upper aerodigestive tract may play a role in the pathogenesis of squamous cell carcinoma of the head and neck. The levels of cyclooxygenase and lipoxygenase metabolites of arachidonic acid metabolism were measured by radioimmunoassay in the saliva of 51 patients with squamous cell carcinoma of the head and neck and compared with a control group of 27 patients with no history of cancer. Levels of leukotriene B4 were significantly increased in cancer patients (p = 0.02), whereas there were no significant differences in levels of prostaglandin E2 or 15-hydroxy-eicosatetranoic acid. Levels of metabolites did not correlate with a history of tobacco use and did not change in a consistent manner after surgery. The significance of arachidonic acid metabolites in the saliva of patients with squamous cell carcinoma of the head and neck is unknown.
上呼吸道和消化道鳞状上皮产生的花生四烯酸代谢产物的改变可能在头颈部鳞状细胞癌的发病机制中起作用。通过放射免疫分析法测定了51名头颈部鳞状细胞癌患者唾液中花生四烯酸代谢的环氧化酶和脂氧化酶代谢产物水平，并与27名无癌症病史的对照组患者进行了比较。癌症患者的白三烯B4水平显著升高（p = 0.02），而前列腺素E2或15-羟基-二十碳四烯酸水平无显著差异。代谢产物水平与吸烟史无关，手术后也没有一致的变化。头颈部鳞状细胞癌患者唾液中花生四烯酸代谢产物的意义尚不清楚。
