el Attar T M, Lin H S, Vanderhoek J Y
Cancer Lett. 1985 Jul;27(3):255-9. doi: 10.1016/0304-3835(85)90182-x.
The metabolism of [14C]arachidonic acid into cyclooxygenase and lipoxygenase products by homogenates of primary squamous carcinomas of head and neck in 12 patients was studied in vitro. The lipoxygenase pathway was predominant in all samples. The major metabolites were 12-hydroxy-5,8,11-14-eicosatetraenoic acid, (12-HETE) and 15-HETE. 5-HETE, 5,12-diHETE, 8-HETE and 9-HETE were also detected. The cyclooxygenase products detected were in the following order: PGE2 greater than PGF2 alpha greater than TxB2 greater than 15-keto-PGE2 greater than 6-keto-PGF1 alpha greater than PGD2. Literature review of the biological activities of these oxygenated metabolites of arachidonic acid suggest important modulatory roles in the pathophysiology of head and neck cancer.
对12例头颈部原发性鳞状细胞癌患者的匀浆在体外将[14C]花生四烯酸代谢为环氧化酶和脂氧化酶产物的情况进行了研究。脂氧化酶途径在所有样本中占主导地位。主要代谢产物为12-羟基-5,8,11,14-二十碳四烯酸（12-HETE）和15-HETE。还检测到了5-HETE、5,12-二HETE、8-HETE和9-HETE。检测到的环氧化酶产物顺序如下：PGE2＞PGF2α＞TxB2＞15-酮-PGE2＞6-酮-PGF1α＞PGD2。对花生四烯酸这些氧化代谢产物的生物学活性进行文献综述表明，它们在头颈部癌症的病理生理学中具有重要的调节作用。
