Ruiz de Almodóvar J M, Ruiz-García J, Olea N, Villalobos M, Pedraza V
Department of Radiology, School of Medicine, University of Granada, Spain.
Radiother Oncol. 1994 Jun;31(3):207-12. doi: 10.1016/0167-8140(94)90425-1.
The records of 231 patients with differentiated thyroid cancer, treated at the University Hospital of Granada between 1972 and 1986, were reviewed to determine which factors were associated with a favourable response and prolonged survival. Radical surgery was the initial treatment in the large majority of the patients. During the postoperative period, 174 patients received 131I therapy and 12 patients were treated by external irradiation. All of them received hormone replacement therapy. Median follow up was over 5 years. Kaplan-Meier actuarial overall survival (S) and disease-free survival (DSF) at 10 years were used as end points for analysis. Survival and freedom from relapse at this time were 0.93 +/- 0.02 and 0.63 +/- 0.06, respectively. No flattening of the relapse curve was observed during the period of follow-up. Univariate analysis showed that the prognosis was significantly influenced by age, sex (papillary cancer only), histological type of tumour, clinical-pathological stage of disease and cervical lymph node status (entire group and papillary cancer). Using Cox's regression model, two groups of patients with low and moderate risk of death and moderate and high risk of recurrence could be identified.
回顾了1972年至1986年间在格拉纳达大学医院接受治疗的231例分化型甲状腺癌患者的记录，以确定哪些因素与良好反应和延长生存期相关。绝大多数患者的初始治疗为根治性手术。术后，174例患者接受了131I治疗，12例患者接受了外照射治疗。所有患者均接受了激素替代治疗。中位随访时间超过5年。采用Kaplan-Meier精算10年总生存率（S）和无病生存率（DSF）作为分析终点。此时的生存率和无复发率分别为0.93±0.02和0.63±0.06。随访期间未观察到复发曲线变平。单因素分析显示，预后受年龄、性别（仅乳头状癌）、肿瘤组织学类型、疾病临床病理分期和颈部淋巴结状态（全部患者及乳头状癌）的显著影响。使用Cox回归模型，可以识别出两组死亡风险低和中等以及复发风险中等和高的患者。
