Ducobu J
Service de Médecine Interne, Hôpital de Tivoli, La Louvière.
Rev Med Brux. 1994 May-Jun;15(3):124-31.
Numerous epidemiological studies have confirmed the positive correlation of elevated serum cholesterol levels to increased coronary risk. Clinical and angiographical trials have shown that modification of hypercholesterolaemia by diet or drugs can lower cardiovascular morbidity and mortality. No good evidence exists that lowering serum cholesterol is harmful. In some meta-analyses enhancing statistical power, total mortality appears to be decreased in primary prevention trials if hypercholesterolaemia is sufficiently reduced. Current guidelines for cholesterol modification should include the primary prevention with identification of individuals at high risk, combined with population information, and the secondary prevention for the patients with symptomatic coronary heart disease.
大量流行病学研究已证实血清胆固醇水平升高与冠心病风险增加呈正相关。临床和血管造影试验表明，通过饮食或药物改善高胆固醇血症可降低心血管疾病的发病率和死亡率。没有充分证据表明降低血清胆固醇有害。在一些增强统计效力的荟萃分析中，如果高胆固醇血症得到充分降低，在一级预防试验中总死亡率似乎会降低。当前的胆固醇改善指南应包括对高危个体进行识别的一级预防，并结合人群信息，以及对有症状冠心病患者的二级预防。
