Ernst E, Nielsen G L, Schmidt E B
Klinisk kemisk afdeling, reumatologisk afdeling og medicinsk-haematologisk afdeling, Aalborg Sygehus.
Ugeskr Laeger. 1994 Jun 6;156(23):3490-5.
Dietary supplementation with polyunsaturated fatty acids--n-3 PUFA or fish oils--has gained increasing interest among patients suffering from rheumatoid arthritis. The biochemical background for the beneficial effects of fish oils in modulating the inflammatory response is briefly described and is partly based on findings from experimental animal models. Ten published double-blind studies evaluating the effect of a daily supplement with three to six grams of n-3 PUFA to patients with active rheumatoid arthritis are reviewed. The studies support a modest effect of fish oil on patient-reported disease parameters without serious side effects. Future research should evaluate effect, tolerance and side effects in long term studies with different daily intakes of n-3 PUFA and should also focus on the effect of n-3 PUFA in combination with standard therapy in patients with rheumatoid arthritis.
用多不饱和脂肪酸（n-3多不饱和脂肪酸或鱼油）进行膳食补充，在类风湿性关节炎患者中越来越受到关注。简要描述了鱼油在调节炎症反应方面有益作用的生化背景，部分基于实验动物模型的研究结果。回顾了十项已发表的双盲研究，这些研究评估了每天给活动性类风湿性关节炎患者补充三至六克n-3多不饱和脂肪酸的效果。这些研究支持鱼油对患者报告的疾病参数有适度影响，且无严重副作用。未来的研究应该在不同每日n-3多不饱和脂肪酸摄入量的长期研究中评估其效果、耐受性和副作用，还应关注n-3多不饱和脂肪酸与类风湿性关节炎患者标准疗法联合使用的效果。
