Roy M A, Flaum M A, Gupta S, Jaramillo L, Andreasen N C
Psychiatric Genetics Program, Medical College of Virginia, Richmond.
Acta Psychiatr Scand. 1994 May;89(5):324-8. doi: 10.1111/j.1600-0447.1994.tb01523.x.
We studied 68 schizophrenic cases with a schizophrenic first-degree relative (familial group) and 62 cases without such a family history (sporadic group). We compared them on: (i) clinical variables, including premorbid adjustment, age of onset and severity of symptoms; (ii) neural abnormalities, including abnormal involuntary movements, neural "soft" and "hard signs"; (iii) neuropsychological tests, including the Wechsler Adult Intelligence Scale and the Continuous Performance Test and (iv) environmental risk factors, including winter birth and obstetrical complications. Sporadic cases were more likely to be born in winter and had more severe psychotic symptoms, but most analyses yielded no difference between the groups. Our results offer some support that sporadic schizophrenia is a more environmental subtype, but they also suggest that the familial vs sporadic distinction of schizophrenia has limited power to identify distinct subgroups.
我们研究了68例有精神分裂症一级亲属的精神分裂症患者（家族组）和62例无此类家族史的患者（散发组）。我们在以下方面对他们进行了比较：（i）临床变量，包括病前适应情况、发病年龄和症状严重程度；（ii）神经异常，包括异常不自主运动、神经“软”体征和“硬”体征；（iii）神经心理测试，包括韦氏成人智力量表和连续操作测试；以及（iv）环境危险因素，包括冬季出生和产科并发症。散发组患者更可能在冬季出生，且有更严重的精神病症状，但大多数分析显示两组之间没有差异。我们的结果为散发型精神分裂症是一种更受环境影响的亚型提供了一些支持，但也表明精神分裂症的家族性与散发性区分在识别不同亚组方面的作用有限。
