Cantor-Graae E, McNeil T F, Sjöström K, Nordström L G, Rosenlund T
Department of Psychiatry, University of Lund, Malmö General Hospital, Sweden.
J Nerv Ment Dis. 1994 Nov;182(11):645-50. doi: 10.1097/00005053-199411000-00008.
The history of obstetric complications was studied in 70 Research Diagnostic Criteria schizophrenic patients and 70 demographically matched controls from the same delivery series, using information prospectively recorded at birth. Schizophrenic patients were exposed to greater numbers of obstetric complications than their matched controls. Rates of obstetric complications were enhanced in patients born during the winter months (January-April) and in patients with no family history of psychosis in first- and second-degree biological relatives. Winter birth was associated with absence of family history of psychosis. Analyses by gender indicated that the relationship between obstetric complications and these other risk factors may be more relevant for male patients. The results suggest that the seasonal effect in schizophrenia may be due partially to seasonal variation in obstetric complications and that obstetric complications and winter birth may represent a distinctively separate etiological mechanism from that of inferred genetic risk for schizophrenia.
利用出生时前瞻性记录的信息，对70名符合研究诊断标准的精神分裂症患者和来自同一分娩队列的70名人口统计学匹配的对照者的产科并发症史进行了研究。精神分裂症患者比其匹配的对照者面临更多的产科并发症。冬季出生（1月至4月）的患者以及一级和二级生物学亲属中无精神病家族史的患者，产科并发症发生率更高。冬季出生与无精神病家族史相关。按性别分析表明，产科并发症与这些其他危险因素之间的关系可能对男性患者更为相关。结果表明，精神分裂症的季节效应可能部分归因于产科并发症的季节性变化，并且产科并发症和冬季出生可能代表了一种与精神分裂症推断遗传风险截然不同的病因机制。
