Häggström J, Hansson K, Karlberg B E, Kvart C, Olsson K
Department of Physiology, Faculty of Veterinary Medicine, University of Agricultural Sciences, Uppsala, Sweden.
Am J Vet Res. 1994 May;55(5):698-703.
Plasma concentration of immunoreactive atrial natriuretic peptide (ir-ANP) was investigated in 83 Cavalier King Charles Spaniels with variable severity of mitral regurgitation caused by chronic valvular disease (CVD). Severity of mitral incompetence was assessed by echocardiography. Significant differences in plasma concentrations of ir-ANP were not found between clinically normal dogs (New York Heart Association functional class O), dogs with only cardiac murmur (class I), and dogs with echocardiographic evidence of slight to moderate left atrial and ventricular dilatation (class II). Dogs with severe left atrial and ventricular dilatation and clinical signs of congestion (classes III and IV) were found to have significantly (P < 0.001) increased plasma concentration of ir-ANP. Overall, moderate degree of association was found between plasma concentration of ir-ANP and left atrial and left ventricular diameters (Pearson's r = 0.65, 0.60, respectively, P < 0.001), as well as heart rate (r = 0.47, P < 0.01). However, left atrial enlargement was found to have the predominant effect on plasma ir-ANP concentration. It is concluded that the plasma concentration of ir-ANP did not become markedly increased before decompensation of chronic mitral regurgitation associated with severe enlargement of the left atrium and ventricle in Cavalier King Charles Spaniels.
在83只患有慢性瓣膜病（CVD）导致不同程度二尖瓣反流的查理士王小猎犬中，研究了免疫反应性心房利钠肽（ir-ANP）的血浆浓度。通过超声心动图评估二尖瓣关闭不全的严重程度。在临床正常的犬（纽约心脏协会心功能分级O级）、仅有心脏杂音的犬（I级）和有超声心动图证据显示左心房和心室轻度至中度扩张的犬（II级）之间，未发现ir-ANP血浆浓度有显著差异。发现有严重左心房和心室扩张及充血临床体征的犬（III级和IV级）的ir-ANP血浆浓度显著升高（P < 0.001）。总体而言，发现ir-ANP血浆浓度与左心房和左心室直径之间存在中度关联（皮尔逊相关系数分别为r = 0.65、0.60，P < 0.001），与心率也存在关联（r = 0.47，P < 0.01）。然而，发现左心房扩大对血浆ir-ANP浓度的影响最为显著。得出的结论是，在查理士王小猎犬中，与严重左心房和心室扩大相关的慢性二尖瓣反流失代偿之前，ir-ANP的血浆浓度并未明显升高。
