Vasikaran S D, McCloskey E V, Kahn S, Kanis J A
WHO Collaborating Centre for Metabolic Bone Disease, University of Sheffield Medical School, UK.
Ann Clin Biochem. 1994 May;31 ( Pt 3):272-6. doi: 10.1177/000456329403100310.
The total intra-individual variation of fasting urinary calcium- and hydroxyproline-creatinine ratios were determined both as outpatients and as inpatients in 46 patients with metabolic bone disorders, including 20 women with osteoporosis. The intra-individual variation of both measurements was reduced considerably by collecting samples in the ward rather than in the outpatient setting, although this was not the case for a sub-group of osteoporotic women. The large intra-individual variation observed for calcium and hydroxyproline (30-40% in osteoporotic women) can give rise to misclassification in screening for fast bone losers. The very large critical difference required (109% and 94%, respectively, for calcium and hydroxyproline) for two results to reflect a significant change, is a major limitation in the use of these analytes for monitoring bone resorption in menopausal and osteoporotic women.
在46例代谢性骨病患者（包括20例骨质疏松症女性患者）中，作为门诊患者和住院患者分别测定了空腹尿钙-肌酐比值和羟脯氨酸-肌酐比值的个体内总变异。通过在病房而非门诊环境采集样本，两种测量的个体内变异均显著降低，尽管骨质疏松症女性亚组并非如此。观察到的钙和羟脯氨酸的个体内变异较大（骨质疏松症女性中为30%-40%），这可能导致在筛查快速骨质流失者时出现错误分类。两个结果要反映出显著变化所需的非常大的临界差异（钙和羟脯氨酸分别为109%和94%），是将这些分析物用于监测绝经后和骨质疏松症女性骨吸收的主要限制因素。
