Need A G, Morris H A, Cleghorn D B, De Nichilo D, Horowitz M, Nordin B E
Division of Clinical Chemistry, Institute of Medical and Veterinary Science, Adelaide, Australia.
Arch Intern Med. 1991 Apr;151(4):757-9.
Fasting calcium and hydroxyproline excretion are related to fasting sodium excretion in postmenopausal women. We postulate that calcium excretion is sodium dependent and that hydroxyproline excretion is calcium dependent. Therefore, we sought to lower urinary hydroxyproline, which is a marker of bone resorption, by lowering urinary sodium. Fasting urine samples were obtained from 59 postmenopausal women before and after 2 to 7 days of dietary salt restriction. The urinary sodium-to-creatinine ratio fell from 16 to 7; calcium to creatinine, 0.30 to 0.26; and hydroxyproline to creatinine, 18.2 to 16.8. In the 28 subjects with starting sodium-to-creatinine ratios greater than 15, the hydroxyproline-to-creatinine ratio fell from 19.6 to 16.3. Salt restriction may be one way of reducing bone resorption in postmenopausal women, particularly in those whose sodium intake is high.
绝经后女性的空腹钙和羟脯氨酸排泄与空腹钠排泄有关。我们推测钙排泄依赖于钠，而羟脯氨酸排泄依赖于钙。因此，我们试图通过降低尿钠来降低作为骨吸收标志物的尿羟脯氨酸。在59名绝经后女性进行2至7天饮食限盐前后采集空腹尿液样本。尿钠与肌酐比值从16降至7；钙与肌酐比值从0.30降至0.26；羟脯氨酸与肌酐比值从18.2降至16.8。在28名起始钠与肌酐比值大于15的受试者中，羟脯氨酸与肌酐比值从19.6降至16.3。限盐可能是减少绝经后女性骨吸收的一种方法，尤其是在钠摄入量高的女性中。
