Konishi T, Hiraishi M, Mafune K, Miyama T, Hirata T, Mori K, Nishina H, Idezuki Y
Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.
Anticancer Res. 1994 May-Jun;14(3B):1277-9.
The therapeutic efficacy and toxicity of sequential methotrexate and 5-fluorouracil in 64 inoperable gastric cancer patients are reported. An intermediate-dose treatment was given to 48 patients, and a low-dose treatment to 16 patients. In the intermediate-dose treatment, leukopenia was observed in 11 patients, nausea and vomiting in six patients and diarrhea and stomatitis in two patients each. In the low-dose treatment, no patient developed toxic symptoms of grade 3 or 4. All 9 responders had adenocarcinoma of the poorly differentiated type and the response rate in patients who belonged to this type was 32.1%.
报告了64例无法手术的胃癌患者序贯使用甲氨蝶呤和5-氟尿嘧啶的治疗效果及毒性。48例患者接受中等剂量治疗，16例患者接受低剂量治疗。在中等剂量治疗中，11例患者出现白细胞减少，6例患者出现恶心和呕吐，各有2例患者出现腹泻和口腔炎。在低剂量治疗中，没有患者出现3级或4级毒性症状。所有9例缓解者均为低分化型腺癌，该类型患者的缓解率为32.1%。
