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High-level resistance to gentamicin in clinical isolates of enterococci.肠球菌临床分离株对庆大霉素的高水平耐药性。
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Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917.粪肠球菌质粒pAD1和pAD2的图谱绘制以及与Tn917转座相关的研究。
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Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes.粪肠球菌发酵变种中质粒介导的多重抗生素抗性的接合转移
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High-content aminoglycoside disks for determining aminoglycoside-penicillin synergy against Enterococcus faecalis.用于确定氨基糖苷类药物与青霉素对粪肠球菌协同作用的高含量氨基糖苷类药敏纸片
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Effects of medium and inoculum variations on screening for high-level aminoglycoside resistance in Enterococcus faecalis.培养基和接种物变化对粪肠球菌高水平氨基糖苷类耐药性筛选的影响
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Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities.粪肠球菌中双功能6'-氨基糖苷乙酰转移酶-2''-氨基糖苷磷酸转移酶基因的核苷酸序列分析以及确定两种活性的基因区域的鉴定与克隆
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Transferable resistance and aminoglycoside-modifying enzymes in enterococci.肠球菌中的可转移耐药性与氨基糖苷类修饰酶
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High-level resistance to gentamicin in clinical isolates of Streptococcus (Enterococcus) faecium.粪肠球菌临床分离株对庆大霉素的高水平耐药性。
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Regulation of the pAD1 sex pheromone response in Enterococcus faecalis: construction and characterization of lacZ transcriptional fusions in a key control region of the plasmid.粪肠球菌中pAD1性信息素反应的调控：质粒关键控制区域中lacZ转录融合体的构建与表征
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Nucleotide sequence analysis of IS256 from the Staphylococcus aureus gentamicin-tobramycin-kanamycin-resistance transposon Tn4001.金黄色葡萄球菌庆大霉素-妥布霉素-卡那霉素抗性转座子Tn4001中IS256的核苷酸序列分析。
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肠球菌中高水平庆大霉素耐药性的转移性及遗传相关性

Transferability and genetic relatedness of high-level gentamicin resistance among enterococci.

作者信息

Sahm D F, Gilmore M S

机构信息

Division of Microbiology and Serology, Jewish Hospital, Washington University Medical Center, St. Louis, Missouri 63110.

出版信息

Antimicrob Agents Chemother. 1994 May;38(5):1194-6. doi: 10.1128/AAC.38.5.1194.

DOI:10.1128/AAC.38.5.1194
PMID:8067764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188178/
Abstract

Gentamicin resistance in six enterococcal species was investigated. Transfer of resistance was observed for the donors E. faecium UC 79, E. avium CC 54, and E. gallinarum B 51, but not for E. raffinosus UC 78 or E. casseliflavus UC 73. Except for E. casseliflavus UC 73, homology was observed between the E. faecalis aac6'-aph2" gene and DNA from other species. Whereas 2.6-kb HindIII fragments encoded resistance in E. faecalis UC 244, its transconjugant, and E. raffinosus UC 78, 3.4-kb fragments encoded resistance in E. faecium UC 79, E. gallinarum B 51, and their transconjugants. A 3.4-kb fragment encoded resistance in E. avium CC 54, but 2.6-kb fragments encoded resistance in the transconjugants. Although many similarities were found among the strains, the heterogeneity in gentamicin resistance exhibited by some isolates indicates diversity among these determinants.

摘要

对六种肠球菌属细菌的庆大霉素耐药性进行了研究。观察到屎肠球菌UC 79、鸟肠球菌CC 54和鹑鸡肠球菌B 51作为供体时耐药性发生了转移，但棉子糖肠球菌UC 78或格氏肠球菌UC 73未发生。除格氏肠球菌UC 73外，粪肠球菌aac6'-aph2"基因与其他物种的DNA之间存在同源性。在粪肠球菌UC 244、其转接合子和棉子糖肠球菌UC 78中，2.6 kb的HindIII片段编码耐药性，而在屎肠球菌UC 79、鹑鸡肠球菌B 51及其转接合子中，3.4 kb的片段编码耐药性。在鸟肠球菌CC 54中，一个3.4 kb的片段编码耐药性，但在其转接合子中，2.6 kb的片段编码耐药性。尽管在这些菌株之间发现了许多相似之处，但一些分离株所表现出的庆大霉素耐药性异质性表明这些决定因素之间存在多样性。