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肠球菌中高水平庆大霉素耐药性的转移性及遗传相关性

Transferability and genetic relatedness of high-level gentamicin resistance among enterococci.

作者信息

Sahm D F, Gilmore M S

机构信息

Division of Microbiology and Serology, Jewish Hospital, Washington University Medical Center, St. Louis, Missouri 63110.

出版信息

Antimicrob Agents Chemother. 1994 May;38(5):1194-6. doi: 10.1128/AAC.38.5.1194.

DOI:10.1128/AAC.38.5.1194
PMID:8067764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188178/
Abstract

Gentamicin resistance in six enterococcal species was investigated. Transfer of resistance was observed for the donors E. faecium UC 79, E. avium CC 54, and E. gallinarum B 51, but not for E. raffinosus UC 78 or E. casseliflavus UC 73. Except for E. casseliflavus UC 73, homology was observed between the E. faecalis aac6'-aph2" gene and DNA from other species. Whereas 2.6-kb HindIII fragments encoded resistance in E. faecalis UC 244, its transconjugant, and E. raffinosus UC 78, 3.4-kb fragments encoded resistance in E. faecium UC 79, E. gallinarum B 51, and their transconjugants. A 3.4-kb fragment encoded resistance in E. avium CC 54, but 2.6-kb fragments encoded resistance in the transconjugants. Although many similarities were found among the strains, the heterogeneity in gentamicin resistance exhibited by some isolates indicates diversity among these determinants.

摘要

对六种肠球菌属细菌的庆大霉素耐药性进行了研究。观察到屎肠球菌UC 79、鸟肠球菌CC 54和鹑鸡肠球菌B 51作为供体时耐药性发生了转移，但棉子糖肠球菌UC 78或格氏肠球菌UC 73未发生。除格氏肠球菌UC 73外，粪肠球菌aac6'-aph2"基因与其他物种的DNA之间存在同源性。在粪肠球菌UC 244、其转接合子和棉子糖肠球菌UC 78中，2.6 kb的HindIII片段编码耐药性，而在屎肠球菌UC 79、鹑鸡肠球菌B 51及其转接合子中，3.4 kb的片段编码耐药性。在鸟肠球菌CC 54中，一个3.4 kb的片段编码耐药性，但在其转接合子中，2.6 kb的片段编码耐药性。尽管在这些菌株之间发现了许多相似之处，但一些分离株所表现出的庆大霉素耐药性异质性表明这些决定因素之间存在多样性。

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