妊娠期急性疱疹性肝炎
Acute herpes hepatitis in pregnancy.
作者信息
Fink C G, Read S J, Hopkin J, Peto T, Gould S, Kurtz J B
机构信息
Department of Clinical Virology, John Radcliffe Hospital, Headington, Oxford.
出版信息
J Clin Pathol. 1993 Oct;46(10):968-71. doi: 10.1136/jcp.46.10.968.
Abstract
A 36 year old primigravid woman presented with a "flu-like" illness and premature labour, followed by severe pneumonitis and hepatitis in the late second trimester of pregnancy. Progressive deterioration obliged an elective delivery of twins, stillborn at 25 weeks of gestation. Herpes virus isolated from one placenta, but not from any fetal tissue, was the only indication of a systemic herpes simplex infection in which there were no mucocutaneous lesions seen before or during the illness. There was no history of herpes simplex infection and antibody studies were not helpful initially for a diagnosis that was confirmed in retrospect. Double staining for viral DNA and antigen showed that the virus was present in host monocytes.
摘要
一名36岁的初产妇出现“流感样”疾病和早产，随后在妊娠晚期出现严重肺炎和肝炎。病情逐渐恶化，不得不选择分娩双胞胎，这对双胞胎在妊娠25周时死产。从一个胎盘分离出疱疹病毒，但未从任何胎儿组织中分离出，这是全身性单纯疱疹感染的唯一迹象，在疾病之前或期间未发现任何黏膜皮肤病变。没有单纯疱疹感染史，抗体研究最初对诊断没有帮助，诊断是在回顾时得到证实的。病毒DNA和抗原的双重染色显示病毒存在于宿主单核细胞中。
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