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冠状动脉瘤血栓形成导致的猝死。两例不典型川崎病病例。

Sudden death caused by thrombosed coronary artery aneurysm. Two unusual cases of Kawasaki disease.

作者信息

Kristensen I B, Kristensen B O

机构信息

Institute of Forensic Medicine, University of Aarhus, Denmark.

出版信息

Int J Legal Med. 1994;106(5):277-80. doi: 10.1007/BF01225421.

DOI:10.1007/BF01225421
PMID:8068575
Abstract

Kawasaki disease primarily affects children below 5 years of age, and fatal coronary complications usually occur within 6-12 months following the acute illness. We report 2 unusual fatal cases of thrombosed coronary artery aneurysms. The first case was an 11-year-old boy, who died suddenly 2 months after the acute illness. He had a classical clinical picture, but was misdiagnosed. The second case was a 29-year-old man without history of recent febrile episodes or cardiac symptoms. Both subjects fulfilled the stage 4 criteria of Kawasaki disease (healing stage) with extensive old myocardial damage. The cases illustrate the great variation in the clinical picture of Kawasaki disease. Teenagers can also be affected, and extensive myocardial damage may be asymptomatic for many years.

摘要

川崎病主要影响5岁以下儿童,致命的冠状动脉并发症通常在急性疾病发作后的6至12个月内发生。我们报告2例罕见的冠状动脉瘤血栓形成致死病例。第一例是一名11岁男孩,在急性疾病发作2个月后突然死亡。他有典型的临床表现,但被误诊。第二例是一名29岁男性,近期无发热病史或心脏症状。两名患者均符合川崎病4期标准(恢复期),伴有广泛的陈旧性心肌损伤。这些病例说明了川崎病临床表现的巨大差异。青少年也可能受到影响,广泛的心肌损伤可能多年无症状。

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Sudden death caused by thrombosed coronary artery aneurysm. Two unusual cases of Kawasaki disease.冠状动脉瘤血栓形成导致的猝死。两例不典型川崎病病例。
Int J Legal Med. 1994;106(5):277-80. doi: 10.1007/BF01225421.
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When children with Kawasaki disease grow up: Myocardial and vascular complications in adulthood.川崎病患儿长大后:成年期的心肌和血管并发症。
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Giant right coronary artery aneurysm presenting as a mediastinal mass.表现为纵隔肿块的巨大右冠状动脉瘤。

本文引用的文献

1
Transformation of coronary artery aneurysm to obstructive lesion and the role of collateral vessels in myocardial perfusion in patients with Kawasaki disease.川崎病患者冠状动脉瘤转变为阻塞性病变及侧支血管在心肌灌注中的作用
J Am Coll Cardiol. 1993 Jan;21(1):158-62. doi: 10.1016/0735-1097(93)90731-f.
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Probable efficacy of high-dose salicylates in reducing coronary involvement in Kawasaki disease.大剂量水杨酸盐在减少川崎病冠状动脉受累方面的可能疗效。
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Frequency and size of coronary arterial aneurysm at necropsy in Kawasaki disease.
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Effect of adopting a new histological grading system of acute rejection after heart transplantation.采用心脏移植术后急性排斥反应新组织学分级系统的效果。
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Long-term prognosis of Kawasaki disease patients with coronary artery obstruction.患有冠状动脉阻塞的川崎病患者的长期预后。
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Coronary artery aneurysms in a young adult.一名年轻成年人的冠状动脉瘤
Am J Forensic Med Pathol. 1989 Mar;10(1):63-6. doi: 10.1097/00000433-198903000-00016.
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Diagnosis and management of Kawasaki disease.川崎病的诊断与管理
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8
Sudden death caused by coronary artery aneurysms: a late complication of Kawasaki disease.冠状动脉瘤导致的猝死:川崎病的晚期并发症。
J Forensic Sci. 1991 Jan;36(1):51-9.
9
Asymptomatic myocardial infarction in Kawasaki disease: long-term prognosis.川崎病中的无症状心肌梗死:长期预后
Pediatr Cardiol. 1991 Apr;12(2):78-82. doi: 10.1007/BF02238407.
10
Mortality among children with Kawasaki disease in Japan.日本川崎病患儿的死亡率。
N Engl J Med. 1992 May 7;326(19):1246-9. doi: 10.1056/NEJM199205073261903.