Mahoney J M, Bachtel M D
Saint Louis College of Pharmacy.
Ann Pharmacother. 1994 May;28(5):587-9. doi: 10.1177/106002809402800507.
To report a case of pleural effusion associated with chronic dantrolene administration.
Case report.
Private, university-affiliated, teaching hospital.
Twelve years after the initiation of low-dose dantrolene therapy for chronic spasticity, a 35-year-old man developed a pleural effusion with pleural and peripheral eosinophilia. This reaction gradually resolved over several months after discontinuation of the dantrolene therapy.
In patients treated with chronic dantrolene therapy, the presence of pleural effusions should raise the suspicion of dantrolene-induced disease. Withdrawal of dantrolene therapy has generally been associated with an alleviation of signs and symptoms within several months.
