Nakatani S, Beppu S, Ohta T, Matsuda H, Miyatake K
Cardiology Division, National Cardiovascular Center, Suita.
Intern Med. 1994 Apr;33(4):204-9. doi: 10.2169/internalmedicine.33.204.
We studied the feasibility and adverse effects of transpulmonary contrast echocardiography using sonicated albumin in 6 dogs. Left heart contrast was observed by two-dimensional echocardiography, monitoring left ventricular pressure, its first derivative (dP/dt) and arterial oxygen saturation. The left heart was adequately opacified in 48 of 55 injections of various intravenous doses of sonicated albumin. Left ventricular myocardial opacification was faintly observed in only 1 injection. After injections of a large dose (0.5 ml/kg), left ventricular systolic pressure decreased, maximal positive dP/dt decreased and negative dP/dt increased, slightly. Hemodynamic parameters showed no significant changes with the other doses. Arterial oxygen saturation tended to decrease after injection, which was most remarkable with a large dose injection. In conclusion, although a large dose of intravenous sonicated albumin may opacify not only the left heart cavity but the ventricular myocardium, it deteriorates hemodynamic parameters and oxygen exchange in the lung.
我们在6只犬中研究了使用超声处理的白蛋白进行经肺对比超声心动图检查的可行性及不良反应。通过二维超声心动图观察左心造影情况，同时监测左心室压力、其一阶导数（dP/dt）及动脉血氧饱和度。在55次不同静脉剂量超声处理白蛋白注射中，48次左心显影良好。仅1次注射后隐约观察到左心室心肌显影。注射大剂量（0.5 ml/kg）后，左心室收缩压降低，最大正dP/dt降低，负dP/dt略有升高。其他剂量下血流动力学参数无显著变化。注射后动脉血氧饱和度有下降趋势，大剂量注射时最为明显。总之，尽管大剂量静脉注射超声处理的白蛋白不仅可使左心腔显影，还可使心室心肌显影，但会使血流动力学参数恶化并影响肺内氧交换。
