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大鼠吸入²²⁷Th后关于肺和骨肿瘤风险的代谢与剂量学研究。

Metabolic and dosimetric studies after inhalation of 227Th in rats with regard to the risk of lung and bone tumors.

作者信息

Müller W A, Nenot J C, Daburon M L, Lafuma J

出版信息

Radiat Environ Biophys. 1975;11(4):309-11. doi: 10.1007/BF01326753.

DOI:10.1007/BF01326753
PMID:806929
Abstract

227Th (alpha-emitter, half-life 18.7 days) was inhaled by rats from solution in nitrate form. Organ doses were calculated after whole body measurements and measuring of activity concentrations in the organs over a longer incorporation period. An initial deposition of 100 nCi 227Th in the lung resulted in mean total doses of 150 rad in lung and 36 rad in bone. The data for kidney and liver were 2 rad and 0.1 rad, respectively. For long-term experiments two dosages were applied to two groups of animals with mean values of 900 rad and 300 rad in the lung. The consequences for lung and bone tumor induction are discussed.

摘要

大鼠吸入了呈硝酸盐形式溶液中的227钍(发射α粒子,半衰期18.7天)。在较长的摄入期内进行全身测量并测量器官中的活度浓度后,计算了器官剂量。肺部初始沉积100纳居里的227钍导致肺部平均总剂量为150拉德,骨骼为36拉德。肾脏和肝脏的数据分别为2拉德和0.1拉德。在长期实验中,对两组动物分别给予两种剂量,肺部的平均值分别为900拉德和300拉德。讨论了对肺部和骨肿瘤诱发的影响。

相似文献

1
Metabolic and dosimetric studies after inhalation of 227Th in rats with regard to the risk of lung and bone tumors.大鼠吸入²²⁷Th后关于肺和骨肿瘤风险的代谢与剂量学研究。
Radiat Environ Biophys. 1975;11(4):309-11. doi: 10.1007/BF01326753.
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本文引用的文献

1
[Precise measurement of the radioactivity of a living animal].[活体动物放射性的精确测量]
J Radiol Electrol Med Nucl. 1962 Jun-Jul;43:409.
2
[Metabolic and therapeutic study of respiratory contamination by various actinic solutions].[各种光化溶液对呼吸道污染的代谢及治疗研究]
Health Phys. 1971 Feb;20(2):167-77. doi: 10.1097/00004032-197102000-00005.
3
Studies on short-lived internal -emitters in mice and rats. II. 227 Th.小鼠和大鼠体内短寿命内发射体的研究。II. 钍-227
Int J Radiat Biol Relat Stud Phys Chem Med. 1971;20(3):233-43. doi: 10.1080/09553007114551131.
4
Late effects after incorporation of the short-lived alpha-emitters 224Ra and 227Th in mice.将短寿命α发射体224Ra和227Th引入小鼠后的远期效应。
Health Phys. 1978 Jul;35(1):33-55. doi: 10.1097/00004032-197807000-00004.