Reed M J, Ho H, Donnelly R, Reaven G M
Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
Blood Press. 1994 May;3(3):197-201. doi: 10.3109/08037059409102253.
It is well-established that diets enriched either with salt or simple sugars are associated with variable increases in blood pressure, but the interrelationship between carbohydrate- and salt-sensitive hypertension has received comparatively little attention. The effects of varying salt intake on blood pressure responses to a fructose-enriched diet were examined in a variety of common laboratory rat strains. Sprague-Dawley, Fischer 344, and Wistar rats were placed on diets enriched in fructose, salt, or a combination of both for 12 days. Measurements of blood pressure (tail-cuff) and fasting plasma insulin concentrations were recorded before and after dietary intervention. In response to the fructose-enriched diet (normal salt), all strains developed a significant increase in plasma insulin (1-2 fold, p < 0.05). However, only Sprague-Dawley rats showed an increase in blood pressure in response to the fructose-enriched diet (21 mmHg, p < 0.05). A high salt diet increased blood pressure only in Fischer 344 rats (10 mmHg, p < 0.05), but the combination of high fructose and high salt increased blood pressure significantly in both Fischer 344 and Wistar rats (mean of 19 mmHg, p < 0.05). In conclusion, the ability of a fructose-enriched diet to increase blood pressure varies as a function of strain, and can be modulated by changes in salt intake.
众所周知，高盐或高单糖饮食与血压的不同程度升高有关，但碳水化合物敏感型高血压和盐敏感型高血压之间的相互关系相对较少受到关注。在多种常见的实验大鼠品系中，研究了不同盐摄入量对富含果糖饮食的血压反应的影响。将斯普拉格-道利大鼠、费希尔344大鼠和Wistar大鼠置于富含果糖、盐或两者组合的饮食中12天。在饮食干预前后记录血压（尾套法）和空腹血浆胰岛素浓度的测量值。对于富含果糖的饮食（正常盐含量），所有品系的血浆胰岛素均显著升高（1 - 2倍，p < 0.05）。然而，只有斯普拉格-道利大鼠对富含果糖的饮食出现血压升高（21 mmHg，p < 0.05）。高盐饮食仅使费希尔344大鼠的血压升高（10 mmHg，p < 0.05），但高果糖和高盐组合使费希尔344大鼠和Wistar大鼠的血压均显著升高（平均19 mmHg，p < 0.05）。总之，富含果糖的饮食升高血压的能力因品系而异，并且可以通过盐摄入量的变化来调节。
