Donnelly R, Ho H, Reaven G M
Department of Medicine, Stanford University School of Medicine, CA, USA.
Blood Press. 1995 May;4(3):164-9. doi: 10.3109/08037059509077589.
Since there appear to be important interactions between mechanisms of salt-sensitive and carbohydrate-sensitive hypertension, the goal of this study was to evaluate the effects of greatly reducing dietary salt intake and removal of one kidney (to increase salt sensitivity) on the hemodynamic and metabolic responses to carbohydrate-enriched diets in three different rat strains. All three strains of laboratory rat developed significant increases in fasting plasma insulin (1-2 fold, p < 0.03) and triglyceride (2-3 fold, p < 0.01) concentrations in response to fructose (or sucrose) enriched diets, irrespective of salt content. Blood pressure increased significantly in response to carbohydrate feeding in both Sprague-Dawley (S-D) and Dahl salt-sensitive rats, but not in Fischer 344 rats, and decreasing salt intake had no effect on the development of carbohydrate-induced hypertension: e.g., delta BP in S-D rats was +20 mmHg after the fructose-0.5% NaCl diet as compared with +19 mmHg after fructose-0.02% NaCl, and delta BP in Dahl salt-sensitive rats was +22 mmHg after fructose-0.02% NaCl. Finally, nephrectomy neither accentuated the degree of hypertension in fructose-fed S-D rats, nor increased blood pressure in fructose-fed Fischer 344 rats. These results emphasize the strain specific characteristics of carbohydrate-induced hypertension in rats, and indicate that the hemodynamic responses of different rat strains to dietary carbohydrate are not modified by either decreasing salt intake or removing one kidney.
由于盐敏感性高血压和碳水化合物敏感性高血压机制之间似乎存在重要相互作用，本研究的目的是评估大幅降低饮食中盐摄入量以及切除一侧肾脏（以增加盐敏感性）对三种不同大鼠品系对富含碳水化合物饮食的血流动力学和代谢反应的影响。所有三种实验室大鼠品系在摄入富含果糖（或蔗糖）的饮食后，无论盐含量如何，空腹血浆胰岛素浓度（升高1 - 2倍，p < 0.03）和甘油三酯浓度（升高2 - 3倍，p < 0.01）均显著增加。在给予碳水化合物后，Sprague-Dawley（S-D）大鼠和Dahl盐敏感性大鼠的血压显著升高，但Fischer 344大鼠没有，并且降低盐摄入量对碳水化合物诱导的高血压的发展没有影响：例如，S-D大鼠在摄入0.5% NaCl的果糖饮食后的血压变化为 +20 mmHg，而在摄入0.02% NaCl的果糖饮食后为 +19 mmHg；Dahl盐敏感性大鼠在摄入0.02% NaCl的果糖饮食后的血压变化为 +22 mmHg。最后，肾切除术既没有加重果糖喂养的S-D大鼠的高血压程度，也没有增加果糖喂养的Fischer 344大鼠的血压。这些结果强调了大鼠碳水化合物诱导的高血压的品系特异性特征，并表明不同大鼠品系对饮食碳水化合物的血流动力学反应不会因降低盐摄入量或切除一侧肾脏而改变。
