Kapur S, Meyer J, Wilson A A, Houle S, Brown G M
Clarke Institute of Psychiatry, University of Toronto, Ont., Canada.
Brain Res. 1994 May 23;646(2):292-4. doi: 10.1016/0006-8993(94)90091-4.
This study investigates the effect of a serotonergic agent, fenfluramine, on neuronal activity, as measured using [18F]fluorodeoxyglucose (FDG) uptake with positron emission tomography (PET) in humans. Eleven subjects each received oral fenfluramine and placebo, on two different occasions, followed by FDG PET scans. Our study shows that fenfluramine modulates ongoing neuronal activity in a regionally specific fashion with a relative increase in metabolism in the prefrontal cortex and a relative decrease in the occipital-temporal regions.
本研究调查了一种血清素能药物芬氟拉明对神经元活动的影响，该影响通过正电子发射断层扫描（PET）测量人体[18F]氟脱氧葡萄糖（FDG）摄取来评估。11名受试者在两个不同的时间段分别口服了芬氟拉明和安慰剂，随后进行了FDG PET扫描。我们的研究表明，芬氟拉明以区域特异性方式调节持续的神经元活动，前额叶皮质的代谢相对增加，枕颞区的代谢相对减少。
