Kapur S, Meyer J, Wilson A A, Houle S, Brown G M
Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, Ont., Canada.
Neurosci Lett. 1994 Jul 18;176(1):21-4. doi: 10.1016/0304-3940(94)90861-3.
The purpose of this study was to investigate the functional effects of apomorphine, a non-selective dopamine agonist, on regional neuronal activity using regional cerebral blood flow, measured using [15O]H2O and positron emission tomography (PET), as an index. Eight normal volunteers were scanned twice before and twice after receiving 10 micrograms/kg subcutaneous apomorphine. Apomorphine produced the expected side-effects and endocrine response. Analysis of the PET scans revealed that apomorphine increased regional cerebral blood flow (rCBF), presumably reflecting a change in neuronal activity, in the anterior cingulate, ventral motor cortex and the dorsolateral prefrontal cortex along with a decrease in rCBF in the retrosplenial cingulate region. These regions form a functional network of brain regions modulated by the dopaminergic system.
本研究的目的是使用[15O]H2O和正电子发射断层扫描（PET）测量的局部脑血流量作为指标，研究非选择性多巴胺激动剂阿扑吗啡对局部神经元活动的功能影响。8名正常志愿者在皮下注射10微克/千克阿扑吗啡之前和之后各进行了两次扫描。阿扑吗啡产生了预期的副作用和内分泌反应。PET扫描分析显示，阿扑吗啡增加了前扣带回、腹侧运动皮层和背外侧前额叶皮层的局部脑血流量（rCBF），这可能反映了神经元活动的变化，同时脾后扣带区的rCBF减少。这些区域形成了一个由多巴胺能系统调节的脑区功能网络。
