Vatta M, Travaglianti M, Bianciotti L, Coll C, Perazzo J, Fernández B
Cátedra de Fisiopatología and Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Brain Res. 1994 May 23;646(2):324-6. doi: 10.1016/0006-8993(94)90099-x.
Atrial natriuretic factor (ANF) effects on norepinephrine (NE) uptake in olfactory bulb, preoptic, periventricular, supraoptic, paraventricular and arcuate nuclei and median eminence of the rat were studied. Experiments were carried out in vitro on nuclei punched out according to the Palkovitz and Brownstein technique. Results showed that 100 nM ANF enhanced NE uptake in all nuclei studied. These data suggest that ANF may be indirectly involved in the regulation of neuroendocrine processes, behavioral arousal, sexual behavior, water and electrolyte balance, arterial blood pressure, etc., through the modulation of central noradrenergic neurotransmission.
研究了心房利钠因子（ANF）对大鼠嗅球、视前区、室周区、视上核、室旁核、弓状核及正中隆起中去甲肾上腺素（NE）摄取的影响。采用帕尔科维茨和布朗斯坦技术在体外对取出的核团进行实验。结果表明，100 nM的ANF可增强所有研究核团中的NE摄取。这些数据表明，ANF可能通过调节中枢去甲肾上腺素能神经传递，间接参与神经内分泌过程、行为觉醒、性行为、水和电解质平衡、动脉血压等的调节。
