Lemberg A, Perazzo J, Romay S, Eizayaga F, Vatta M, Rodriguez-Fermepin M, Bianciotti L, Monserrat A, Fernandez B
Cátedras de Fisiopatología y Fisiología (Prosivad-Conicet), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Brain Res Bull. 1998;45(2):153-6. doi: 10.1016/s0361-9230(97)00331-6.
Several evidences support the hypothesis that central catecholamines may play a significant role in the production and/or maintenance of different alterations that characterize portal hypertension. The aim of the present work was to study the possible modifications in norepinephrine (NE) metabolism in several telencephalic and diencephalic areas rich in NE in experimental prehepatic portal hypertension. NE uptake was studied as an index of NE metabolism. The experiments were carried out in vitro in encephalic areas and nuclei, obtained according to the punch-out technique. Results indicated that portal hypertensive rats showed an enhancement of NE uptake in olfactory bulb (OB), preoptic area (PA), and supraoptic, periventricular, paraventricular, and arcuate nuclei (SON, PeVN, PaVN, and AN, respectively) compared to sham-operated rats. However, no modifications on NE uptake was observed in the median eminence (ME). Present results suggest that the changes observed in central NE uptake may be related to the development and/or maintenance of the portal hypertensive state.
多项证据支持这样一种假说，即中枢儿茶酚胺可能在门静脉高压所特有的不同改变的产生和/或维持中发挥重要作用。本研究的目的是探讨实验性肝前性门静脉高压时，几个富含去甲肾上腺素（NE）的端脑和间脑区域中NE代谢的可能变化。研究NE摄取作为NE代谢的一个指标。实验在根据打孔技术获得的脑区和核团中进行体外实验。结果表明，与假手术大鼠相比，门静脉高压大鼠的嗅球（OB）、视前区（PA）以及视上核、室周核、室旁核和弓状核（分别为SON、PeVN、PaVN和AN）中NE摄取增强。然而，在正中隆起（ME）未观察到NE摄取的改变。目前的结果表明，中枢NE摄取的变化可能与门静脉高压状态的发展和/或维持有关。
