Huang J L, Lin C J, Hung I J, Luo S F
Department of Pediatrics, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Changgeng Yi Xue Za Zhi. 1994 Jun;17(2):113-20.
From 1977 till 1991, the diagnosis of systemic lupus erythematosus was made on 137 children aged 18 years or under in Chang Gung Memorial Hospital. The medical records were reviewed and the clinical data were analysed with emphasis on the morbidity and mortality of this disease. The clinical and laboratory characteristics were similar to the findings from most other reports. Renal failure accounted for 8% of the initial presentation. The non-infectious complications were, in the order of frequencies, hypertension, avascular necrosis of femoral head, cataract, encephalopathy, and venous thrombosis. Sepsis, cutaneous infection and urinary tract infection were the frequently encountered infectious complications. The major causes of death in childhood onset systemic lupus erythematosus were sepsis (42%) and renal failure (30.7%). Forty patients were lost to follow-up. The 5-year survival rate, calculated by life-table, was 76.3%.
1977年至1991年期间，长庚纪念医院对137名18岁及以下儿童进行了系统性红斑狼疮的诊断。回顾了病历并分析了临床数据，重点关注该疾病的发病率和死亡率。临床和实验室特征与大多数其他报告的结果相似。肾衰竭占初始表现的8%。非感染性并发症按发生频率依次为高血压、股骨头缺血性坏死、白内障、脑病和静脉血栓形成。败血症、皮肤感染和尿路感染是常见的感染性并发症。儿童期系统性红斑狼疮的主要死亡原因是败血症（42%）和肾衰竭（30.7%）。40名患者失访。通过生命表计算的5年生存率为76.3%。
