Jensovský J, Andĕl M, Stolba P
II. interní klinika 3. LF UK, Praha.
Cas Lek Cesk. 1994 Jul 18;133(14):419-22.
Impairment of the vascular endothelium and its functions is a common sign of several serious diseases (atherosclerosis, hypertension, vascular spasms, thromboses) and is the initial stage of vascular affection in diabetes mellitus. The endothelium plays an important role in the transformation of some substances with a cardiovascular action and it secretes itself vasoactive substances. Vascular affections in diabetes are characterized by impaired homeostasis of vasoactive substances of endothelial origin--raised levels of vasoconstrictor factors (endothelins, thromboxanes) and reduction of vasodilatating factors (prostacyclin, EDRF--endothelin derived relaxing factor) as well as disorders of their interrelations. Vasoactive agents lead at the same time also to alteration of the growth and proliferation potential of smooth muscle cells of the vascular wall and thus to remodelling of the vascular structure in diabetes. At present possible ways how to influence these processes in a favourable way are intensely studied and discussed.
血管内皮及其功能受损是多种严重疾病（动脉粥样硬化、高血压、血管痉挛、血栓形成）的常见体征，也是糖尿病血管病变的初始阶段。内皮在一些具有心血管作用的物质转化过程中起重要作用，并且自身分泌血管活性物质。糖尿病中的血管病变以内皮源性血管活性物质的内环境稳态受损为特征——血管收缩因子（内皮素、血栓素）水平升高，血管舒张因子（前列环素、内皮衍生舒张因子）减少，以及它们之间相互关系的紊乱。血管活性药物同时也导致血管壁平滑肌细胞生长和增殖潜能的改变，从而导致糖尿病患者血管结构的重塑。目前，如何以有利的方式影响这些过程的可能方法正在深入研究和讨论。
