Malhotra R, Lu J, Holmskov U, Sim R B
Department of Biochemistry, University of Oxford, UK.
Clin Exp Immunol. 1994 Aug;97 Suppl 2(Suppl 2):4-9. doi: 10.1111/j.1365-2249.1994.tb06254.x.
The collectins are a group of soluble multimeric lectins, which contain collagenous segments, and resemble the complement protein C1q in aspects of their structures and functions. This group of proteins, which includes MBP, SP-A, SP-D, conglutinin and CL-43, are known to act as opsonins in various circumstances, and are likely to have roles in innate immunity. The focus of current research is to pursue the hypothesis that the collectins recognize and bind to non-host carbohydrate structures on microorganisms and particles, and participate in the processing or elimination of such material, either by direct interaction with phagocytic cell receptors, or by indirect routes such as complement activation .
凝集素是一组可溶性多聚体凝集素，含有胶原片段，在结构和功能方面类似于补体蛋白C1q。这组蛋白质包括甘露聚糖结合凝集素（MBP）、表面活性蛋白A（SP-A）、表面活性蛋白D（SP-D）、胶固素和CL-43，已知它们在各种情况下可作为调理素，并且可能在先天免疫中发挥作用。当前研究的重点是探究这样一种假说，即凝集素识别并结合微生物和颗粒上的非宿主碳水化合物结构，并通过与吞噬细胞受体的直接相互作用，或通过补体激活等间接途径，参与此类物质的处理或清除。
