Holmskov U, Malhotra R, Sim R B, Jensenius J C
Dept of Medical Microbiology, University of Odense, Denmark.
Immunol Today. 1994 Feb;15(2):67-74. doi: 10.1016/0167-5699(94)90136-8.
Collectins are humoral lectins found in mammals and birds. They are oligomers whose subunits comprise three polypeptide chains each containing a collagenous section and a C-terminal lectin domain. They are related structurally and functionally to the first component of the classical complement pathway, C1q, and seem to serve important roles in innate immunity through opsonization and complement activation. The lectin domains bind carbohydrates on microorganisms, while the collagenous regions are ligands for the collectin receptor on phagocytes and also mediate C1q-independent activation of the classical complement pathway.
凝集素是在哺乳动物和鸟类中发现的体液凝集素。它们是寡聚体，其亚基由三条多肽链组成，每条多肽链都包含一个胶原区和一个C端凝集素结构域。它们在结构和功能上与经典补体途径的第一成分C1q相关，并且似乎通过调理作用和补体激活在先天免疫中发挥重要作用。凝集素结构域与微生物上的碳水化合物结合，而胶原区是吞噬细胞上凝集素受体的配体，也介导经典补体途径的C1q非依赖性激活。
