Barry-Kinsella C, Sharma S C, Cottell E, Harrison R F
Royal College of Surgeons in Ireland, Department of Obstetrics and Gynaecology, Rotunda Hospital, Dublin.
Eur J Obstet Gynecol Reprod Biol. 1994 Apr;54(2):113-8. doi: 10.1016/0028-2243(94)90248-8.
Serum and peritoneal fluid concentrations of progesterone and 17 beta-oestradiol were measured during days 20-27 of the luteal phase in 33 women with minimal stage endometriosis and 21 with unexplained infertility. The results were analysed using Student's t-test and straight line regression analysis. In both groups, 17 beta-oestradiol and progesterone values were several-fold higher than the corresponding serum values and there were significant correlations between the peritoneal fluid and the serum steroid values. In the peritoneal fluid there was a significant reduction in both progesterone and its ratio with 17 beta-oestradiol in women with minimal stage endometriosis (P < 0.03, P < 0.04, respectively). The peritoneal fluid levels of 17 beta-oestradiol in women with minimal stage endometriosis were, however, not significantly altered. Despite the correlations between peritoneal fluid and serum steroid levels, there were no significant changes in the serum concentrations of progesterone, 17 beta-oestradiol or the ratio of progesterone to 17 beta-oestradiol in women with minimal stage endometriosis. It is concluded that luteal phase progesterone and its relationship to 17 beta-oestradiol are subtly altered in infertile women with minimal stage endometriosis compared with women with unexplained infertility. These alterations may be more clearly demonstrated in peritoneal fluid rather than in peripheral blood, possibly because the latter contains steroids which are of non-ovarian origin and are also constantly affected by the liver enzyme activity and enterohepatic circulation of individual subjects.
在黄体期的第20 - 27天，对33例轻度子宫内膜异位症患者和21例不明原因不孕症患者的血清及腹腔液中的孕酮和17β - 雌二醇浓度进行了测定。结果采用学生t检验和直线回归分析进行分析。在两组中，17β - 雌二醇和孕酮值均比相应的血清值高出数倍，且腹腔液与血清类固醇值之间存在显著相关性。在轻度子宫内膜异位症患者的腹腔液中，孕酮及其与17β - 雌二醇的比值均显著降低（分别为P < 0.03，P < 0.04）。然而，轻度子宫内膜异位症患者腹腔液中17β - 雌二醇水平无显著变化。尽管腹腔液与血清类固醇水平之间存在相关性，但轻度子宫内膜异位症患者血清中孕酮、17β - 雌二醇浓度或孕酮与17β - 雌二醇的比值均无显著变化。结论是，与不明原因不孕症患者相比，轻度子宫内膜异位症不孕症患者黄体期孕酮及其与17β - 雌二醇的关系发生了细微改变。这些改变在腹腔液中可能比在外周血中表现得更明显，这可能是因为外周血中含有非卵巢来源的类固醇，且个体的肝酶活性和肠肝循环也会持续影响外周血中的类固醇。
