Ortega-Moreno J
Department of Animal Pathology, University of Zaragoza, Spain.
Eur J Obstet Gynecol Reprod Biol. 1994 Apr;54(2):123-6. doi: 10.1016/0028-2243(94)90250-x.
In order to obtain more detailed information about the validity of the rat as an endometriotic experimental model, endometriosis was surgically induced in 48 female Wistar rats, and the estrogen (ERc) and progesterone (PRc) receptor concentrations present in experimental endometriosis and endometrium were compared in the four estrous phases (n = 12). Lower values of ERc were found in endometriosis than in endometrium (proestrus, 156.27 +/- 24.09 vs. 195.27 +/- 32.13 pmol/g tissue, P < 0.05; estrus, 302.33 +/- 45.16 vs. 335.67 +/- 44.82 pmol/g tissue, P < 0.05; metestrus, 166.60 +/- 26.09 vs. 193.30 +/- 22.04 pmol/g tissue, P < 0.05; diestrus, 130.27 +/- 20.58 vs. 135.81 +/- 16.25 pmol/g tissue, P > 0.05; Student's t-test). As in the case of ERc, lower PRc were observed in endometriotic than in endometrial tissues (proestrus, (proestrus, 137.83 +/- 22.64 vs. 176.54 +/- 21.78 pmol/g tissue, P < 0.05; estrus, 242.10 +/- 34.78 vs. 286.20 +/- 31.74 pmol/g tissue, P < 0.05; metestrus, 194.36 +/- 35.08 vs. 224.73 +/- 20.21 pmol/g tissue, P < 0.05; diestrus, 147.72 +/- 26.21 vs. 147.33 +/- 22.65 pmol/g tissue, P > 0.05; Student's t-test). Similar ERc/PRc ratios were found for both the endometriotic and the endometrial tissues (proestrus, 1.14 +/- 0.07 vs. 1.08 +/- 0.09, P > 0.05; estrus, 1.29 +/- 0.19 vs. 1.21 +/- 0.18, P > 0.05; metestrus, 0.87 +/- 0.14 vs. 0.89 +/- 0.11 P > 0.05; diestrus, diestrus, 0.89 +/- 0.06 vs. 0.92 +/- 0.06, P > 0.05; Student's t-test, NS).(ABSTRACT TRUNCATED AT 250 WORDS)
为了获取关于大鼠作为子宫内膜异位症实验模型有效性的更详细信息，对48只雌性Wistar大鼠进行手术诱导子宫内膜异位症，并在四个发情期（n = 12）比较实验性子宫内膜异位症和子宫内膜中存在的雌激素（ERc）和孕激素（PRc）受体浓度。发现子宫内膜异位症中的ERc值低于子宫内膜（动情前期，156.27±24.09对195.27±32.13 pmol/g组织，P < 0.05；发情期，302.33±45.16对335.67±44.82 pmol/g组织，P < 0.05；间情期，166.60±26.09对193.30±22.04 pmol/g组织，P < 0.05；动情后期，130.27±20.58对135.81±16.25 pmol/g组织，P > 0.05；学生t检验）。与ERc情况相同，子宫内膜异位组织中的PRc低于子宫内膜组织（动情前期，137.83±22.64对176.54±21.78 pmol/g组织，P < 0.05；发情期，242.10±34.78对286.20±31.74 pmol/g组织，P < 0.05；间情期，194.36±35.08对224.73±20.21 pmol/g组织，P < 0.05；动情后期，147.72±26.21对147.33±22.65 pmol/g组织，P > 0.05；学生t检验）。子宫内膜异位组织和子宫内膜组织的ERc/PRc比值相似（动情前期，1.14±0.07对1.08±0.09，P > 0.05；发情期，1.29±0.19对1.21±0.18，P > 0.05；间情期，0.87±0.14对0.89±0.11，P > 0.05；动情后期，0.89±0.06对0.92±0.06，P > 0.05；学生t检验，无显著性差异）。（摘要截断于250字）
