Richards R G, Almond G W
Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Inflammation. 1994 Apr;18(2):203-14. doi: 10.1007/BF01534561.
The increase in steroid hormone blood levels in response to bacterial lipopolysaccharide (LPS) appears to be an important mechanism by which mammalian species regulate inflammation. This study examined changes in serum concentrations of cortisol, progesterone, and 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) in diestrous pigs following the intravenous injection of LPS and determined whether indomethacin would attenuate these changes. Serum cortisol and progesterone concentrations increased (P < 0.05) within 30 min after the administration of LPS, and the increases in steroid hormones were accompanied by a sharp, transient increase (P < 0.05) in PGFM levels. In the presence of indomethacin, serum PGFM levels did not change (P > 0.05); however, LPS enhanced (P < 0.05) cortisol and progesterone concentrations, although the increases were delayed. Serum concentrations of cortisol acutely increased (P < 0.05) immediately following both infusions of indomethacin. In summary, cortisol and progesterone concentrations increased irrespective of serum PGFM concentrations, thereby indicating that prostaglandin F2 alpha was not the sole mediator of LPS-induced changes in cortisol and progesterone concentrations.
响应细菌脂多糖（LPS）时甾体激素血水平的升高似乎是哺乳动物调节炎症的一种重要机制。本研究检测了处于发情间期的母猪静脉注射LPS后血清皮质醇、孕酮和13,14-二氢-15-酮-前列腺素F2α（PGFM）浓度的变化，并确定吲哚美辛是否会减弱这些变化。给予LPS后30分钟内，血清皮质醇和孕酮浓度升高（P<0.05），甾体激素的升高伴随着PGFM水平急剧、短暂的升高（P<0.05）。在吲哚美辛存在的情况下，血清PGFM水平未发生变化（P>0.05）；然而，LPS使皮质醇和孕酮浓度升高（P<0.05），尽管升高出现延迟。两次输注吲哚美辛后，血清皮质醇浓度立即急剧升高（P<0.05）。总之，无论血清PGFM浓度如何，皮质醇和孕酮浓度均升高，从而表明前列腺素F2α不是LPS诱导的皮质醇和孕酮浓度变化的唯一介质。
